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Not sure if I'll do more beyond giving the options, these women seemed like good matches. I couldn't think of a very good way to describe their problems the same way AppleShadow did. I'll give more detail below, spoilers involved.
Eleanor Varrot comes from Valkyria Chronicles, she stuck around in the military because her lover was killed in action and treated inhumanely by a general from the enemy forces. During the game, she abuses her power to send her troops on an unauthorized mission to kill that general.
Queen Zeal comes from Chrono Trigger, and I was especially thinking about how she's willing to sacrifice her own daughter to get more power. She's also abusive when it comes to humans with no magic power.
Katherine McBride comes from Catherine, doesn't really threaten violence, but Vincent fears she might get that way. Dream Katherine murders Catherine, too. She doesn't quite lie, but when she finds out she's not pregnant anymore, she doesn't tell Vincent to try to make him stay. Vincent's reckless with money, that's why she controls their finances.
Lithariel's from Shadow of Mordor, and there's a story mission where she was reckless enough to get her men killed and herself captured by Sauron's forces. The player has to go rescue her, and she doesn't show much regret over the loss of lives for her recklessness.
Stacey Forsythe comes from Dead Rising 2. I liked the idea of her considered a public nuisance. The endangerment part is sort of a "from Phenotrans' perspective" deal. They can claim C.U.R.E. radicalizes people, and that not culling zombies for entertainment puts people at risk.
I like how this whole thread has a lot of options that are very well thought out, but nobody has actually started a damn thuing.
I'm not sure how long my own interest in this idea will last if it goes anywhere, and I've come to a point of waiting for other people to write an episode to show their interest before I commit much of my own. I got bored with writing a lot of episodes that nobody was interested in after a while.
I really like these, I'm glad people have taken an interest. Though I confess the only character I truly recognise is Katherine. I might do something for her sometime, but I'm currently working on an extension for one of the Anime characters at the moment.